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DMPK studies are conducted to determine the disposition of the drug and its metabolites using suitable animal models. At IIRT we offer the following DMPK services

§  Single or multiple dose (s) – in mice & rats

§  Oral &/or IV or IP (or intended) route

§  2-6 animals/dose; 5-12 time points / client specific designs

§  PK study in cannulated animals as per client's requirement

§  Tissue distribution studies

§  In -vivo blood – brain barrier penetration studies

End-points

§  Oral BA

§  Elimination half life (t1/2) Renal Clearance (Cl) Volume Distribution (Vd), AUC, Under Area Curve; Maximum Plasma Concentration;

§  Metabolite identification